Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.

Letter by Lin et al regarding article, "Nitric oxide scavenging of red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion".

Nitric oxide scavenging by red cell microparticles and cell free hemoglobin as a mechanism for hemolytic diseases and the red blood cell storage lesion

Intravascular red cell hemolysis impairs NO-redox homeostasis, producing endothelial dysfunction, platelet activation and vasculopathy. A central mechanism is that cell-free plasma hemoglobin reacts with the vasodilator nitric oxide (NO) in a 1:1 stoichiometric reaction that occurs at high rate of 6-8x107 mol/L/s. This consumption of NO by cell free plasma hemoglobin has been shown to cause cha...

Mechanism of faster NO scavenging by older stored red blood cells☆

UNLABELLED The blood storage lesion involves morphological and biochemical changes of red blood cells (RBCs) that occur during storage. These include conversion of the biconcave disc morphology to a spherical one, decreased mean corpuscular hemoglobin concentration, varied mean corpuscular volume, reduced integrity of the erythrocyte membrane with formation of microparticles, and increased cell...

Epidural anesthesia at the Pitié-Salpêtrière Hospital: from Fernand Cathelin (1901) to Jeanne Seebacher (1974).

12. Roback JD: Vascular effects of the red blood cell storage lesion. Hematology Am Soc Hematol Educ Program 2011; 2011:475–9 13. Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT: Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a me...

Evaluation of Blood Storage Lesions in Leuko-depleted Red Blood Cell Units

Background: Red blood cells (RBCs) undergo biochemical and morphologic alterations during storage that are known as the storage lesions causing decreased RBC quality and are correlated with transfusion reactions in certain groups especially in infants and critically ill patients. Microvesicles (MVs) as one of storage lesions may be derived from various cell types and have key roles in several...